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Nourish and Hydrate With Squalene

Revitalize Aging Feet The Importance of Proactive Skin / Foot Care

LE Magazine

Gary Goldfaden, MD

Another natural substance that has the power to soothe and heal your skin / feet is squalene.

Squalene is a biochemical precursor in the body’s synthesis of cholesterol. It is also one of the principal hydrocarbons contained in the protective surface lipids of the skin, where it amounts to approximately 15% of the total fat content, although this declines substantially with aging. {18} Distributed widely throughout most of nature, squalene is found in everything from the liver of deep sea sharks to vegetable sources like olive, palm, wheat germ, and rice bran oils.

Truly one of nature’s great emollients, squalene is quickly and efficiently absorbed deep into the skin, restoring healthy suppleness and flexibility without leaving an oily residue. This highly effective natural moisturizer is great at replenishing missing oils and soothing dry, rough, or sun-exposed skin. It’s no wonder that countless generations of fishermen from Scandinavia, Japan, and the South Pacific have used fish oils rich in squalene for healing the irritated skin of their faces and hands. Squalene from olive oil is generally preferred for dermatological use, however, because of its greater stability. Olive oil contains about 0.2-0.7% squalene. {19}

In addition to its ability to naturally nourish and hydrate tissue, evidence suggests that squalene may help fight dangerous bacteria that can infect the skin. {20}

Squalene also has potent antioxidant effects that may benefit skin health. Experimental evidence indicates that squalene is a highly effective oxygen-scavenging agent. {21} Squalene’s molecular composition allows it to donate electrons in order to neutralize dangerous peroxide radicals. Squalene has a chemical structure that is similar to vitamin A, allowing it to protect the skin surface from lipid peroxidation due to UV exposure and other sources of oxidative stress. Squalene’s powerful free radical-quenching ability has been shown to be equal to that of butylated hydroxytoluene or BHT, one of the most powerful antioxidants known to science. {21}

Squalene not only inhibits the growth of disease-causing microorganisms, but also moisturizes, heals, and nourishes the skin of your feet, leaving them looking younger and feeling silky soft and smooth.


1.     Available at: Accessed June 20, 2008.

2.     Anjos JL, Neto DS, Alonso A. Effects of 1,8-cineole on the dynamics of lipids and
        proteins of stratum corneum. Int J Pharm. 2007 Dec 10;345(1-2):81-7.

3.     Saify ZS, Ahsan O, Dayo A. Cineole as skin penetration enhancer. Pak J Pharm
        Sci. 2000 Jan;13(1):29-32.

4.     Ashour HM. Antibacterial, antifungal, and anticancer activities of volatile oils
        and extracts from stems, leaves, and flowers of Eucalyptus sideroxylon
        and Eucalyptus torquata. Cancer Biol Ther. 2007 Dec 2;7(3).

5.     Silva J, Abebe W, Sousa SM, et al. Analgesic and anti-inflammatory effects of
        essential oils of Eucalyptus. J Ethnopharmacol. 2003 Dec;89(2-3):277-83.

6.     Tsuzuki K, Xing H, Ling J, Gu JG. Menthol-induced Ca2+ release from presynaptic
        Ca2+ stores potentiates sensory synaptic transmission.
        J Neurosci. 2004 Jan 21;24(3):762-71.

7.     Bautista DM, Siemens J, Glazer JM, et al. The menthol receptor TRPM8 is the
        principal detector of environmental cold. Nature. 2007 Jul 12;448(7150):204-8.

8.     Macpherson LJ, Hwang SW, Miyamoto T, et al. More than cool: promiscuous
        relationships of menthol and other sensory compounds. Mol Cell Neurosci.
        2006 Aug;32(4):335-43.

9.     Futami T. Actions and mechanisms of counterirritants on the muscular circulation.
        Nippon Yakurigaku Zasshi. 1984 Mar;83(3):219-26.

10.   Pattnaik S, Subramanyam VR, Bapaji M, Kole CR. Antibacterial and antifungal
        activity of aromatic constituents of essential oils. Microbios. 1997;89(358):39-46.

11.   McKay DL, Blumberg JB. A review of the bioactivity of South African herbal
         teas: rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia).
         Phytother Res. 2007 Jan;21(1):1-16.

12.   Ojo OO, Ladeji O, Nadro MS. Studies of the antioxidative effects of green and
         black tea (Camellia sinensis) extracts in rats. J Med Food. 2007 Jun;10(2):345-9.

13.   Gawlik M, Czajka A. The effect of green, black and white tea on the level of alpha and
         gamma tocopherols in free radical-induced oxidative damage of human red
         blood cells. Acta Pol Pharm. 2007 Mar;64(2):159-64.

14.   Katiyar SK. Skin photoprotection by green tea: antioxidant and immunomodulatory
         effects. Curr Drug Targets Immune Endocr Metabol Disord. 2003 Sep;3(3):234-42.

15.   du TR, Volsteedt Y, Apostolides Z. Comparison of the antioxidant content
         of fruits, vegetables and teas measured as vitamin C equivalents. Toxicology.
         2001 Sep 14;166(1-2):63-9.

16.   Wha KS, Lee IW, Cho HJ, et al. Fibroblasts and ascorbate regulate epidermalization
         in reconstructed human epidermis. J Dermatol Sci. 2002 Dec;30(3):215-23.

17.   Bell E, Rosenberg M, Kemp P, et al. Recipes for reconstituting skin. J Biomech Eng. 1991

18.   Passi S, De PO, Puddu P, Littarru GP. Lipophilic antioxidants in human sebum
         and aging. Free Radic Res. 2002 Apr;36(4):471-7.

19.   Smith TJ. Squalene: potential chemopreventive agent. Expert Opin Investig Drugs. 2000

20.   Wille JJ, Kydonieus A. Palmitoleic acid isomer (C16:1delta6) in human skin
         sebum is effective against gram-positive bacteria. Skin Pharmacol Appl Skin
         Physiol. 2003 May;16(3):176-87.

21.   Kohno Y, Egawa Y, Itoh S, et al. Kinetic study of quenching reaction of singlet
         oxygen and scavenging reaction of free radical by squalene in n-butanol.
         Biochim Biophys Acta. 1995 Apr 28;1256(1):52-6.

22.   Amarasiri WA, Dissanayake AS. Coconut fats. Ceylon Med J. 2006 Jun;51(2):47-51.

23.   Kirszberg C, Esquenazi D, Alviano CS, Rumjanek VM. The effect of a catechin-rich
         extract of Cocos nucifera on lymphocytes proliferation.
         Phytother Res. 2003 Nov;17(9):1054-8.

24.   Ogbolu DO, Oni AA, Daini OA, Oloko AP. In vitro antimicrobial properties of coconut
         oil on Candida species in Ibadan, Nigeria.J Med Food. 2007 Jun;10(2):384-7.

25.   Carpo BG, Verallo-Rowell VM, Kabara J. Novel antibacterial activity of monolaurin
         compared with conventional antibiotics against organisms from skin infections:
         an in vitro study. J Drugs Dermatol. 2007 Oct;6(10):991-8.

26.   Maranz S, Wiesman Z. Influence of climate on the tocopherol content of shea butter.
         J Agric Food Chem. 2004 May 19;52(10):2934-7.

27.   Rona C, Vailati F, Berardesca E. The cosmetic treatment of wrinkles.
         J Cosmet Dermatol. 2004 Jan;3(1):26-34.

28.   Burke KE. Interaction of vitamins C and E as better cosmeceuticals. Dermatol Ther. 2007

29.   Thiele JJ, Ekanayake-Mudiyanselage S. Vitamin E in human skin: organ-specific
         physiology and considerations for its use in dermatology.
         Mol Aspects Med. 2007 Oct;28(5-6):646-67.

30.   Available at:
         Accessed June 20, 2008.

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